Steve's Talking Clock
If you wish for the days of the Sharp Talking Time I, Vox Clock II, or just love talking clocks in general, then this is the program for you! It has been written specifically to be easily customizable and non-intrusive. With support for eight kinds of clocks and over 50 downloadable voices,... By being able to live in the Windows system tray, Steve's Talking Clock can remain on all the time without getting in the way. ... download the Steve's Talking Clock 2. ... You can configure hotkeys to speak the time, move the main voice up or down, show and hide the window, and exit the program.
http://clock.steve-audio.net/StevesClock2_Setup.exe - 2Mb - Download

Talking Reminder
Never forget another event again with this great looking reminder and calendar that even talks to you! Talking Reminder will keep track of your important events and remind you about them using speech, sound, alert window, email, or file execution. Talking Reminder is fun and easy to use. ... You can change the recurrence at any time. ... You can schedule events on a daily, weekly, monthly and yearly basis or as a one time occurrence. ... It takes no time to enter a new reminder and it will even offer to pre-remind you automatically before the main event.
http://www.softwareriver.com/download/talkingreminder_20.exe - 2Mb - Download - Screenshot

Toolfish Utility Suite
Toolfish Utility Suite is a 19-in-one talking tray application that promises to save you time and make your life easier by performing many useful tasks for you! Web Compare - Automatically checks web pages at timed intervals for changes using advanced fuzzy logic and notifies you based on... Site Monitor - Get notified when a site, email server or port is unavailable and keep statistics (notification by email, audio, running a program and pop-ups supported) Talking Reminders - Use the One-Time or Recurring Reminder Wizard to quickly add a talking reminder, never forget an important event...
http://www.rtsoft.com/ToolfishInstaller.exe - 1Mb - Download - Screenshot

CommCenter
Wouldn't it be great to be able to hear your opponents cursing, or to talk with your teammates to coordinate your attack? CommCenter works in the background while you play today's hottest games (like Quake 3 Arena and Unreal Tournament), letting you use your microphone to talk with other players. ... Whether you're hosting a LAN party or playing against friends over lunch at work, CommCenter is a great way to get talking--you don't even need to have your LAN hooked up to the internet for CommCenter to work.
http://www.randomly.com/pub/ccenter.zip - 3Mb - Download - Screenshot

ESDi
Talk to one or more people at the same time via your PC using this intercom application. Designed for your local area network. Talk directly to a particular person or talk to a group. Groups are made up of people working on the same project or in the same department etc.
http://www.enigmasoftwaredevelopments.com/SETUPi.EXE - 160Kb - Download - Screenshot

Talk Radio Tour
Hosted by The Real Deal with George and Sy, Talk Radio Tour is a freeware media organizer software product that allows the die-hard talk radio fan to store favorite talk radio show information, tune in / listen to live talk on the internet, and of course dial in to participate with a simple... Talk Radio Tour is hosted by The Real Deal With George & Syl Website - Providing talk radio where everyone and anyone is invited to voice controversial opinions every Tuesday via the internet during your appropriate time zone (6:00 PM to 8:00 AM PST).
http://members.aol.com/realdealrep/talkradio.zip - 230Kb - Download - Screenshot

One Clock
One Clock is the only clock you'll ever need. It's like a grandfather clock for your computer. One Clock is a talking clock that sits in your system tray. At your selected time interval, either every 5 minutes, 15 minutes, 30 minutes, or 1 hour, One Clock will play a chime and announce the... You have the option to turn both the chime and the spoken voice time announcement on or off. ... If knowing the time is important to you, give One Clock a try. ... And there are eight chimes that you can choose from.
http://www.directlogic.com/pad/ocsetup.exe - 2Mb - Download - Screenshot

AccuBell Talking Caller ID
Free 15 Days Trial. AccuBell Talking Caller ID announces the incoming phone call with caller number and identification of local or long distance call. Pop-up window shows callers Name, Number, Date and Time before you answer. Date and Time have region and country choices. ... Stores unlimited calls log history with full sorting capability of callers name, number, date and time. ... Instantly Zap any unwanted incoming call. ... Call Forwarding feature let you take all incoming call to your Mobile phone during Internet session or when outside home.
http://www.accubell.com/Download/Accsetup.exe - 2Mb - Download - Screenshot

Chuzzles Chess Puzzles Pop-up For Your Desktop
Chess Puzzles for your desktop! Sits in your tray so you can pop it up any time. Simple click and move allows you to enjoy a Chuzzle Chess Puzzle while talking on the phone. Hee hee.
http://www.katachess.com/chuzzles.exe - 2Mb - Download - Screenshot

DeskBot
DeskBot is a free, multi-featured Clipboard Reader, Text Reader, Time Announcer, and Internet Explorer Add-In for Microsoft Windows which Microsoft Agent Animated, Talking Characters. From the developer of MASH - The Microsoft Agent Scripting Helper.
http://www.bellcraft.com/download/deskbot_full_setup.exe - 1Mb - Download - Screenshot